Association of Acute Gastroesophageal Reflux Disease With Esophageal Histologic Changes.

ABSTRACT:

Importance

The histologic changes associated with acute gastroesophageal reflux disease (GERD) have not been studied prospectively in humans. Recent studies in animals have challenged the traditional notion that reflux esophagitis develops when esophageal surface epithelial cells are exposed to lethal chemical injury from refluxed acid.

Objective

To evaluate histologic features of esophageal inflammation in acute GERD to study its pathogenesis.

Design, setting, and participants

Patients from the Dallas Veterans Affairs Medical Center who had reflux esophagitis successfully treated with proton pump inhibitors (PPIs) began 24-hour esophageal pH and impedance monitoring and esophagoscopy (including confocal laser endomicroscopy [CLE]) with biopsies from noneroded areas o

SUBMITTER: Dunbar KB 

PROVIDER: S-EPMC5030713 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature