Early High-Dose Caffeine Increases Seizure Burden in Extremely Preterm Neonates: A Preliminary Study.

ABSTRACT: Background: Although evidence suggests that methylxanthines may lower the seizure threshold, the effect of high-dose caffeine on seizure burden in preterm infants is not known. This study reports a secondary post hoc analysis of a randomized controlled trial of early high-dose caffeine citrate therapy in preterm infants, evaluating the effect of caffeine on the seizure burden using amplitude-integrated electroencephalography (aEEG). Methods: Seventy-four preterm infants (≤30 weeks gestation) were randomized to receive high-dose (n = 37, 80 mg/kg over 36 hours) or standard-dose (n = 37, 30 mg/kg over 36 hours) caffeine citrate over the first 36 hours followed by standard maintenance therapy. Simultaneous recording of two-channel amplitude-int

SUBMITTER: Vesoulis ZA 

PROVIDER: S-EPMC5031091 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature