Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder.

ABSTRACT:

Introduction

Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains.

Methods

Parkinson's Progression Markers Initiative (PPMI) is a multi-site, international study of PD patients untreated at enrollment. pRBD was assessed with the REM sleep behavior disorder questionnaire (RBDSQ). Global cognition was assessed at baseline and annually using the Montreal Cognitive Assessment (MoCA) and a cognitive battery. Linear mixed effects models were used to examine the relationship between pRBD (RBDSQ≥6) and rate of change in cognitive variables.

SUBMITTER: Chahine LM 

PROVIDER: S-EPMC5031362 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature