Ontology highlight
ABSTRACT:
SUBMITTER: Takeuchi Y
PROVIDER: S-EPMC5031553 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Cell reports 20160818 9
Hepatic lipogenesis is nutritionally regulated (i.e., downregulated during fasting and upregulated during the postprandial state) as an adaptation to the nutritional environment. While alterations in the expression level of the transcription factor SREBP-1c are known to be critical for nutritionally regulated lipogenesis, upstream mechanisms governing Srebf1 expression remain unclear. Here, we show that the fasting-induced transcription factor KLF15, a key regulator of gluconeogenesis, forms a c ...[more]