Association of Environmental Toxins With Amyotrophic Lateral Sclerosis.

ABSTRACT:

Importance

Persistent environmental pollutants may represent a modifiable risk factor involved in the gene-time-environment hypothesis in amyotrophic lateral sclerosis (ALS).

Objective

To evaluate the association of occupational exposures and environmental toxins on the odds of developing ALS in Michigan.

Design, setting, and participants

Case-control study conducted between 2011 and 2014 at a tertiary referral center for ALS. Cases were patients diagnosed as having definitive, probable, probable with laboratory support, or possible ALS by revised El Escorial criteria; controls were excluded if they were diagnosed as having ALS or another neurodegenerative condition or if they had a family history of ALS in a first- or second-degree blood relative. Participants comple

SUBMITTER: Su FC 

PROVIDER: S-EPMC5032145 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature