Repair of human periodontal bone defects by autologous grafting stem cells derived from inflammatory dental pulp tissues.

ABSTRACT:

Background

Recently, stem cells derived from inflammatory dental pulp tissues (DPSCs-IPs) have demonstrated regenerative potential, but the real effect remains to be examined. This pilot study attempted to isolate DPSCs-IPs from two patients and to evaluate the feasibility and the effect of reconstructing periodontal intrabone defects in each patient.

Methods

DPSCs-IPs were harvested from two patients with periodontal intrabone defects with their approval. After discussing the biological characteristics of DPSCs-IPs in each patient, DPSCs-IPs were loaded onto the scaffold material β-tricalcium phosphate and engrafted into the periodontal defect area in the root furcation. After 1, 3, and 9 months, the outcome was evaluated by clinical assessment and radiological study. Furth

SUBMITTER: Li Y 

PROVIDER: S-EPMC5032237 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature