Diagnostic accuracy of magnetic resonance elastography in liver transplant recipients: A pooled analysis.

ABSTRACT:

Background and aims

We conducted an individual participant data (IPD) pooled analysis on the diagnostic accuracy of magnetic resonance elastography (MRE) to detect fibrosis stage in liver transplant recipients.

Material and methods

Through a systematic literature search, we identified studies on diagnostic performance of MRE for staging liver fibrosis, using liver biopsy as gold standard. We contacted study authors for published and unpublished IPD on age, sex, body mass index, liver stiffness, fibrosis stage, degree of inflammation and interval between MRE and biopsy; from these we limited analysis to patients who had undergone liver transplantation. Through pooled analysis using nonparametric two-stage receiver-operating curve (ROC) regression models, we calculated the clu

SUBMITTER: Singh S 

PROVIDER: S-EPMC5032623 | biostudies-literature | 2016 May-Jun

REPOSITORIES: biostudies-literature