AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Purpose

Head and neck squamous cell carcinoma (HNSCC) represents the eighth most common malignancy worldwide. Standard-of-care treatments for patients with HNSCC include surgery, radiation, and chemotherapy. In addition, the anti-EGFR monoclonal antibody cetuximab is often used in combination with these treatment modalities. Despite clinical success with these therapeutics, HNSCC remains a difficult malignancy to treat. Thus, identification of new molecular targets is critical.

Experimental design

In the current study, the receptor tyrosine kinase AXL was investigated as a molecular target in HNSCC using established cell lines, HNSCC patient-derived xenografts (PDX), and human tumors. HNSCC dependency on AXL was evaluated with both anti-AXL siRNAs and the small-molecule AXL

SUBMITTER: Brand TM 

PROVIDER: S-EPMC5032632 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature