Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age.

ABSTRACT: Offspring of long-lived families are characterized by beneficial metabolic phenotypes in glucose and lipid metabolism and low 25-hydroxyvitamin D. Although the genetic basis for human longevity remains largely unclear, the contribution of variation at the APOE locus has been repeatedly demonstrated. We aimed to assess whether ApoE isoforms mark the familial longevity status in middle age and subsequently to test to what extend this association is mediated by the metabolic characteristics marking this status. From the Leiden Longevity Study (LLS), we included offspring from nonagenarian siblings and partners as controls. Using the metabolic phenotypes of familial longevity as mediators, we investigated how APOE gene variants associated with LLS offspring/control status (in 1,515 LLS offspri

SUBMITTER: Noordam R 

PROVIDER: S-EPMC5032696 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature