Development of a Semiquantitative Histological Score for the Diagnosis of Heaves Using Endobronchial Biopsy Specimens in Horses.

ABSTRACT:

Background

Remodeling of the peripheral airways persists during the asymptomatic phase of heaves. Assessing the histology of large bronchi could facilitate the diagnosis of heaves during remission of the disease.

Hypothesis

Airway inflammation and remodeling in endobronchial biopsy (EBB) specimens differentiate horses with heaves from controls, independently of their clinical status (exacerbation or remission).

Animals

Fourteen healthy horses and 24 horses with heaves.

Methods

A 14-point scoring system assessing central bronchial wall inflammation and remodeling was developed. The score was validated by 2 pathologists using specimens obtained from 18 horses (6 controls, 6 with heaves exacerbation, and 6 with heaves remission) in which lung function had been ass

SUBMITTER: Bullone M 

PROVIDER: S-EPMC5032871 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature