PRL-3 promotes migration and invasion and is associated with poor prognosis in salivary adenoid cystic carcinoma.

ABSTRACT:

Background

PRL-3 had been found to be involved in tumorigenesis in various malignancies. In this study, we investigated the role of PRL-3 in the development, migration, and invasion of salivary adenoid cystic carcinoma (SACC).

Methods

Immunohistochemistry (IHC) was used to analyze the role of PRL-3 in the development and prognosis of SACC. Then, we overexpressed or inhibited the expression of PRL-3 in paired SACC cells to analyze the role of PRL-3 in the migration and invasion of SACC. In vitro migration and invasion assays were used. Western blotting was used to detect metastasis-related protein levels.

Results

IHC results confirmed that the deregulation of PRL-3 was a frequent event in SACC; the upregulation of PRL-3 was related to clinical stages, vital status, and

SUBMITTER: Dong Q 

PROVIDER: S-EPMC5032974 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature