Impaired planning in Parkinson's disease is reflected by reduced brain activation and connectivity.

ABSTRACT:

Objective

Parkinson's disease (PD) often entails impairments of executive functions, such as planning. Although widely held that these impairments arise from dopaminergic denervation of the striatum, not all executive functions are affected early on, and the underlying neural dynamics are not fully understood. In a combined longitudinal and cross-sectional study, we investigated how planning deficits progress over time in the early stages of PD compared to matched healthy controls. We used functional magnetic resonance imaging (fMRI) to identify accompanying neural dynamics.

Methods

Seventeen PD patients and 20 healthy controls performed a parametric Tower of London task at two time points separated by ∼3 years (baseline and follow-up). We assessed task performance longitudi

SUBMITTER: Trujillo JP 

PROVIDER: S-EPMC5033031 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature