The Stepwise Approach to Diabetes Prevention: Results From the D-CLIP Randomized Controlled Trial.

ABSTRACT:

Objective

This study tests the effectiveness of expert guidelines for diabetes prevention: lifestyle intervention with addition of metformin, when required, among people with prediabetes.

Research design and methods

The Diabetes Community Lifestyle Improvement Program (D-CLIP) is a randomized, controlled, translation trial of 578 overweight/obese Asian Indian adults with isolated impaired glucose tolerance (iIGT), isolated impaired fasting glucose (iIFG), or IFG+IGT in Chennai, India. Eligible individuals were identified through community-based recruitment and randomized to standard lifestyle advice (control) or a 6-month, culturally tailored, U.S. Diabetes Prevention Program-based lifestyle curriculum plus stepwise addition of metformin (500 mg, twice daily) for participant

SUBMITTER: Weber MB 

PROVIDER: S-EPMC5033082 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature