Microbiome Composition and Function Drives Wound-Healing Impairment in the Female Genital Tract.

ABSTRACT: The mechanism(s) by which bacterial communities impact susceptibility to infectious diseases, such as HIV, and maintain female genital tract (FGT) health are poorly understood. Evaluation of FGT bacteria has predominantly been limited to studies of species abundance, but not bacterial function. We therefore sought to examine the relationship of bacterial community composition and function with mucosal epithelial barrier health in the context of bacterial vaginosis (BV) using metaproteomic, metagenomic, and in vitro approaches. We found highly diverse bacterial communities dominated by Gardnerella vaginalis associated with host epithelial barrier disruption and enhanced immune activation, and low diversity communities dominated by Lactobacillus species that associated with lower Nugent scor

SUBMITTER: Zevin AS 

PROVIDER: S-EPMC5033340 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature