Aberrant Methylation of MGMT Promoter in HNSCC: A Meta-Analysis.

ABSTRACT:

Background

O6-methylguanine-DNA methyl-transferase (MGMT) gene, a DNA repair gene, plays a critical role in the repair of alkylated DNA adducts that form following exposure to genotoxic agents. MGMT is generally expressed in various tumors, and its function is frequently lost because of hypermethylation in the promoter. The promoter methylation of MGMT has been extensively investigated in head and neck squamous cell carcinoma (HNSCC). However, the association between the promoter methylation of MGMT and HNSCC risk remains inconclusive and inconsistent. Therefore, we performed a meta-analysis to better clarify the association between the promoter methylation of MGMT and HNSCC risk.

Methods

A systematical search was conducted in PubMed, Web of Science, EMBASE, and Ovid for stu

SUBMITTER: Cai F 

PROVIDER: S-EPMC5033341 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature