Impact of Microbiota on Resistance to Ocular Pseudomonas aeruginosa-Induced Keratitis.

ABSTRACT: The existence of the ocular microbiota has been reported but functional analyses to evaluate its significance in regulating ocular immunity are currently lacking. We compared the relative contribution of eye and gut commensals in regulating the ocular susceptibility to Pseudomonas aeruginosa-induced keratitis. We find that in health, the presence of microbiota strengthened the ocular innate immune barrier by significantly increasing the concentrations of immune effectors in the tear film, including secretory IgA and complement proteins. Consistent with this view, Swiss Webster (SW) mice that are typically resistant to P. aeruginosa-induced keratitis become susceptible due to the lack of microbiota. This was exemplified by increased corneal bacterial burden and elevated pathology of the ger

SUBMITTER: Kugadas A 

PROVIDER: S-EPMC5033354 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature