Ontology highlight
ABSTRACT:
SUBMITTER: Carias AM
PROVIDER: S-EPMC5033389 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
PLoS pathogens 20160922 9
Currently, there are mounting data suggesting that HIV-1 acquisition in women can be affected by the use of certain hormonal contraceptives. However, in non-human primate models, endogenous or exogenous progestin-dominant states are shown to increase acquisition. To gain mechanistic insights into this increased acquisition, we studied how mucosal barrier function and CD4+ T-cell and CD68+ macrophage density and localization changed in the presence of natural progestins or after injection with hi ...[more]