Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases.

ABSTRACT: Methylation of DNA and histone proteins are mutually involved in the epigenetic regulation of gene expression mediated by DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs). DNMTs methylate cytosine residues within gene promoters, whereas HMTs catalyze the transfer of methyl groups to lysine and arginine residues of histone proteins, thus causing chromatin condensation and transcriptional repression, which play an important role in the pathogenesis of cancer. The potential reversibility of epigenetic alterations has encouraged the development of dual pharmacologic inhibitors of DNA and histone methylation as anticancer therapeutics. Dietary flavones can affect epigenetic modifications that accumulate over time and have shown anticancer properties, which are undefined. Thr

SUBMITTER: Kanwal R 

PROVIDER: S-EPMC5033486 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature