A Genome-Wide Association Study of Attention Function in a Population-Based Sample of Children.

ABSTRACT:

Background

Attention function filters and selects behaviorally relevant information. This capacity is impaired in some psychiatric disorders and has been proposed as an endophenotype for Attention-Deficit/Hyperactivity Disorder; however, its genetic basis remains largely unknown. This study aimed to identify single nucleotide polymorphism (SNPs) associated with attention function.

Materials and methods

The discovery sample included 1655 children (7-12 years) and the replication sample included 546 children (5-8 years). Five attention outcomes were assessed using the computerized Attentional Network Test (ANT): alerting, orienting, executive attention, Hit Reaction time (HRT) and the standard error of HRT (HRTSE). A Genome-wide Association Study was conducted for each outcome

SUBMITTER: Alemany S 

PROVIDER: S-EPMC5033492 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature