Molecular Evolution of MDM1, a "Duplication-Resistant" Gene in Vertebrates.

ABSTRACT:

Background

The mouse double minute 1 (Mdm1) gene was first reported and cloned in mouse tumor cell lines as an oncogene candidate. Later, it was found that mutation of Mdm1 might cause age-related retinal degeneration 2 in mice by genetic linkage analysis. Additionally, the MDM1 protein was found to be expressed in the centrosomes, cilia, and the nucleus of multiciliated tracheal epithelial cells in mice. These observations suggest that MDM1 may have some basal functions in cell physiology. However, the evolutionary history of this gene and its expression during embryonic development remain largely unexplored.

Results

Using molecular phylogenetic analysis, we found that the MDM1 gene encoded an evolutionarily conserved protein across all metazoans. We also found that the MDM

SUBMITTER: Hensley MR 

PROVIDER: S-EPMC5033493 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature