Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease.

ABSTRACT: Regulatory T cells (Tregs) play a crucial role in the maintenance of peripheral tolerance. Quantitative and/or qualitative defects in Tregs result in diseases such as autoimmunity, allergy, malignancy, and graft-versus-host disease (GVHD), a serious complication of allogeneic stem cell transplantation (SCT). We recently reported increased expression of autophagy-related genes (Atg) in association with enhanced survival of Tregs after SCT. Autophagy is a self-degradative process for cytosolic components that promotes cell homeostasis and survival. Here, we demonstrate that the disruption of autophagy within FoxP3⁺ Tregs (B6.Atg7^fl/fl-FoxP3cre⁺ ) resulted in a profound loss of Tregs, particularly within the bone marrow (BM). This resulted in dys

SUBMITTER: Le Texier L 

PROVIDER: S-EPMC5033749 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature