Bladder catheterization increases susceptibility to infection that can be prevented by prophylactic antibiotic treatment.

ABSTRACT: Catheter-associated urinary tract infections (CAUTI) are the most common hospital-associated infections. Here, we report that bladder catheterization initiated a persistent sterile inflammatory reaction within minutes of catheter implantation. Catheterization resulted in increased expression of genes associated with defense responses and cellular migration, with ensuing rapid and sustained innate immune cell infiltration into the bladder. Catheterization also resulted in hypersensitivity to Enterococcus faecalis and uropathogenic Escherichia coli (UPEC) infection, in which colonization was achieved using an inoculum 100-fold lower than the ID₉₀ for infection of an undamaged urothelium with the same uropathogens. As the time of catheterization increased, however, co

SUBMITTER: Rousseau M 

PROVIDER: S-EPMC5033754 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature