Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata.

ABSTRACT:

Background

Alopecia areata (AA) is an autoimmune disease characterized by hair loss mediated by CD8⁺ T cells. There are no reliably effective therapies for AA. Based on recent developments in the understanding of the pathomechanism of AA, JAK inhibitors appear to be a therapeutic option; however, their efficacy for the treatment of AA has not been systematically examined.

Methods

This was a 2-center, open-label, single-arm trial using the pan-JAK inhibitor, tofacitinib citrate, for AA with >50% scalp hair loss, alopecia totalis (AT), and alopecia universalis (AU). Tofacitinib (5 mg) was given twice daily for 3 months. Endpoints included regrowth of scalp hair, as assessed by the severity of alopecia tool (SALT), duration of hair growth after completion of therapy,

SUBMITTER: Kennedy Crispin M 

PROVIDER: S-EPMC5033755 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature