Incomplete clonal deletion as prerequisite for tissue-specific minor antigen tolerization.

ABSTRACT: Central clonal deletion has been considered the critical factor responsible for the robust state of tolerance achieved by chimerism-based experimental protocols, but split-tolerance models and the clinical experience are calling this assumption into question. Although clone-size reduction through deletion has been shown to be universally required for achieving allotolerance, it remains undetermined whether it is sufficient by itself. Therapeutic Treg treatment induces chimerism and tolerance in a stringent murine BM transplantation model devoid of myelosuppressive recipient treatment. In contrast to irradiation chimeras, chronic rejection (CR) of skin and heart allografts in Treg chimeras was permanently prevented, even in the absence of complete clonal deletion of donor MHC-reactive T cel

SUBMITTER: Pilat N 

PROVIDER: S-EPMC5033814 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature