PRL3-zumab, a first-in-class humanized antibody for cancer therapy.

ABSTRACT: Novel, tumor-specific drugs are urgently needed for a breakthrough in cancer therapy. Herein, we generated a first-in-class humanized antibody (PRL3-zumab) against PRL-3, an intracellular tumor-associated phosphatase upregulated in multiple human cancers, for unconventional cancer immunotherapies. We focused on gastric cancer (GC), wherein elevated PRL-3 mRNA levels significantly correlated with shortened overall survival of GC patients. PRL-3 protein was overexpressed in 85% of fresh-frozen clinical gastric tumor samples examined but not in patient-matched normal gastric tissues. Using human GC cell lines, we demonstrated that PRL3-zumab specifically blocked PRL-3⁺, but not PRL-3^-, orthotopic gastric tumors. In this setting, PRL3-zumab had better therapeutic e

SUBMITTER: Thura M 

PROVIDER: S-EPMC5033845 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature