Uptake of silver nanoparticles by monocytic THP-1 cells depends on particle size and presence of serum proteins.

ABSTRACT: Human health risks by silver nanoparticle (AgNP) exposure are likely to increase due to the increasing number of NP-containing products and demonstrated adverse effects in various cell lines. Unfortunately, results from (toxicity) studies are often based on exposure dose and are often measured only at a fixed time point. NP uptake kinetics and the time-dependent internal cellular concentration are often not considered. Macrophages are the first line of defense against invading foreign agents including NPs. How macrophages deal with the particles is essential for potential toxicity of the NPs. However, there is a considerable lack of uptake studies of particles in the nanometer range and macrophage-like cells. Therefore, uptake rates were determined over 24 h for three different AgNPs sizes

SUBMITTER: Kettler K 

PROVIDER: S-EPMC5034003 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature