Detection of Human Immunodeficiency Virus Type 1 (HIV-1) A/AE Circulating Recombinant Form (CRF) in India: Possible Implications.

ABSTRACT:

Background

Rapidly evolving viruses such as human immunodeficiency virus (HIV-1) develop marked sequence differences in their genome over the course of an epidemic and in individuals infected for longer duration. This is because of the error prone reverse transcriptase (RT), which rapidly incorporates mutations resulting in genomic diversity, altered cell tropism, immune escape, and variable resistance to antiretroviral drugs. As a result, radically different genomic combinations may be generated in individuals infected by genetically diverse viruses that have mosaic genomes.

Methods

Whole blood sample was collected from 25 HIV-1 infected patients. Chromosomal DNA was isolated from the patient's peripheral blood mononuclear cells (PBMCs). Full-length gag gene (~1.5 kb) was a

SUBMITTER: Gupta RM 

PROVIDER: S-EPMC5034182 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature