Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis.

ABSTRACT:

Objective

ACPAs are associated with bone destruction in RA. The aim of this study was to evaluate the association between ACPA and bone destruction in patients with a distinct inflammatory disorder, PsA.

Methods

We used baseline data from a large observational study of PsA patients preparing to initiate treatment with adalimumab to analyse demographic and disease characteristics by ACPA status. To ensure a homogeneous PsA study population, only patients with active psoriatic skin manifestations who met Classification of Psoriatic Arthritis criteria for PsA were included in the analyses, thereby minimizing the risk of including misdiagnosed RA patients. Multiple logistic regression analyses were used to explore potential associations between ACPA seropositivity and bone destr

SUBMITTER: Behrens F 

PROVIDER: S-EPMC5034218 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature