In-silico insights on the prognostic potential of immune cell infiltration patterns in the breast lobular epithelium.

ABSTRACT: Scattered inflammatory cells are commonly observed in mammary gland tissue, most likely in response to normal cell turnover by proliferation and apoptosis, or as part of immunosurveillance. In contrast, lymphocytic lobulitis (LLO) is a recurrent inflammation pattern, characterized by lymphoid cells infiltrating lobular structures, that has been associated with increased familial breast cancer risk and immune responses to clinically manifest cancer. The mechanisms and pathogenic implications related to the inflammatory microenvironment in breast tissue are still poorly understood. Currently, the definition of inflammation is mainly descriptive, not allowing a clear distinction of LLO from physiological immunological responses and its role in oncogenesis remains unclear. To gain insights int

SUBMITTER: Alfonso JC 

PROVIDER: S-EPMC5034260 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature