Genome-wide mapping of nucleosome positions in Saccharomyces cerevisiae in response to different nitrogen conditions.

ABSTRACT: Well-organized chromatin is involved in a number of various transcriptional regulation and gene expression. We used genome-wide mapping of nucleosomes in response to different nitrogen conditions to determine both nucleosome profiles and gene expression events in Saccharomyces cerevisiae. Nitrogen conditions influence general nucleosome profiles and the expression of nitrogen catabolite repression (NCR) sensitive genes. The nucleosome occupancy of TATA-containing genes was higher compared to TATA-less genes. TATA-less genes in high or low nucleosome occupancy, showed a significant change in gene coding regions when shifting cells from glutamine to proline as the sole nitrogen resource. Furthermore, a correlation between the expression of nucleosome occupancy induced NCR sensitive genes or

SUBMITTER: Zhang P 

PROVIDER: S-EPMC5034280 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature