Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice.

ABSTRACT: Inflammatory bowel disease is characterized by dysregulation of the mucosal immune system resulting from impaired intestinal epithelial barrier function. Protein kinase D2 has been implicated in the regulation of immune responses. The present study was to define PKD2 might affect murine colitis. Colitis was induced in wild-type mice (PKD2^WT/WT) and PKD2 catalytic activity deficient mice (PKD2^SSAA/SSAA) with dextran sulfate sodium. PKD2^SSAA-knockin mice displayed catalytic activity deficiency and increased susceptibility to DSS-induced colitis with enhanced weight loss, colonic inflammation compared with PKD2^WT/WT mice. Furthermore, crucial inflammatory cytokines mRNA levels in PKD2^SSAA-knockin mice were higher than controls accompanied

SUBMITTER: Xiong J 

PROVIDER: S-EPMC5034322 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature