The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats.

ABSTRACT:

Objective

Adult neurogenesis in the subgranular zone and subventricular zone is generally accepted, but its existence in other brain areas is still controversial. Circumventricular organs, such as the area postrema (AP) have recently been described as potential neurogenic niches in the adult brain. The AP is the major site of action of the satiating hormone amylin. Amylin has been shown to promote the formation of neuronal projections originating from the AP in neonatal rodents but the role of amylin in adult neurogenesis remains unknown.

Methods

To test this, we first performed an RNA-sequencing of the AP of adult rats acutely injected with either amylin (20 μg/kg), amylin plus the amylin receptor antagonist AC187 (500 μg/kg) or vehicle. Second, animals were subcutaneously

SUBMITTER: Liberini CG 

PROVIDER: S-EPMC5034493 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature