Physiological role for leptin in the control of thermal conductance.

ABSTRACT:

Objective

To investigate the role played by leptin in thermoregulation, we studied the effects of physiological leptin replacement in leptin-deficient ob/ob mice on determinants of energy balance, thermogenesis and heat retention under 3 different ambient temperatures.

Methods

The effects of housing at 14 °C, 22 °C or 30 °C on core temperature (telemetry), energy expenditure (respirometry), thermal conductance, body composition, energy intake, and locomotor activity (beam breaks) were measured in ob/ob mice implanted subcutaneously with osmotic minipumps at a dose designed to deliver a physiological replacement dose of leptin or its vehicle-control.

Results

As expected, the hypothermic phenotype of ob/ob mice was partially rescued by administration of leptin at a dose

SUBMITTER: Kaiyala KJ 

PROVIDER: S-EPMC5034509 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature