Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons.

ABSTRACT:

Objective

Adiponectin receptors (AdipoRs) are located on neurons of the hypothalamus involved in metabolic regulation - including arcuate proopiomelanocortin (Pomc) and Neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons. AdipoRs play a critical role in regulating glucose and fatty acid metabolism by initiating several signaling cascades overlapping with Leptin receptors (LepRs). However, the mechanism by which adiponectin regulates cellular activity in the brain remains undefined.

Methods

In order to resolve this issue, we utilized neuron-specific transgenic mouse models to identify Pomc and NPY/AgRP neurons which express LepRs for patch-clamp electrophysiology experiments.

Results

We found that leptin and adiponectin synergistically activated melanocortin neuro

SUBMITTER: Sun J 

PROVIDER: S-EPMC5034606 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature