α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors.

ABSTRACT:

Objective

Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) plays a role in glucose homeostasis and tested the hypothesis that the pituitary is able to sense a physiological increase in circulating glucose and responds by secreting α-MSH.

Methods

We established glucose-stimulated α-MSH secretion using humans, non-human primates, and mouse models. Continuous α-MSH infusions were performed during glucose tolerance tests and hyperinsulinemic-euglycemic clamps to evaluate the systemic effect of α-MSH in glucose regulation. Complementary ex vivo and in vitro techniques were employed to delineate t

SUBMITTER: Enriori PJ 

PROVIDER: S-EPMC5034615 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature