DNA methylation and smoking in Korean adults: epigenome-wide association study.

ABSTRACT:

Background

Exposure to cigarette smoking can increase the risk of cancers and cardiovascular and pulmonary diseases. However, the underlying mechanisms of how smoking contributes to disease risks are not completely understood. Epigenome-wide association studies (EWASs), mostly in non-Asian populations, have been conducted to identify smoking-associated methylation alterations at individual probes. There are few data on regional methylation changes in relation to smoking. Few data link differential methylation in blood to differential gene expression in lung tissue.

Results

We identified 108 significant (false discovery rate (FDR) < 0.05) differentially methylated probes (DMPs) and 87 significant differentially methylated regions (DMRs) (multiple-testing corrected p < 

SUBMITTER: Lee MK 

PROVIDER: S-EPMC5034618 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature