The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets.

ABSTRACT:

Objective

G protein-coupled receptor (GPCR) signaling regulates insulin secretion and pancreatic β cell-proliferation. While much knowledge has been gained regarding how GPCRs are activated in β cells, less is known about the mechanisms controlling their deactivation. In many cell types, termination of GPCR signaling is controlled by the family of Regulators of G-protein Signaling (RGS). RGS proteins are expressed in most eukaryotic cells and ensure a timely return to the GPCR inactive state upon removal of the stimulus. The aims of this study were i) to determine if RGS16, the most highly enriched RGS protein in β cells, regulates insulin secretion and β-cell proliferation and, if so, ii) to elucidate the mechanisms underlying such effects.

Methods

Mouse and human islets we

SUBMITTER: Vivot K 

PROVIDER: S-EPMC5034687 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature