Familial Risk of Sjogren's Syndrome and Co-aggregation of Autoimmune Diseases in Affected Families: A Nationwide Population Study.

ABSTRACT:

Objective

To investigate familial aggregation of Sjögren's syndrome (SS) and the relative risks (RRs) of other autoimmune disease in relatives of patients with SS.

Methods

We identified 23,658,577 beneficiaries enrolled in the Taiwan National Health Insurance system in 2010, of whom 12,754 had SS. We identified 21,009,551 parent-child relationships and 17,168,340 pairs of full siblings. The familial risks of SS and other autoimmune diseases, tetrachoric correlation, and familial transmission were estimated.

Results

We identified 105 patients with SS who had an affected first-degree relative. The RR of SS was 18.99 (95% confidence interval [95% CI] 9.76-36.93) in siblings of patients with SS, 11.31 (95% CI 8.34-15.33) in offspring, and 12.46 (95% CI 9.34-16.62) in pare

SUBMITTER: Kuo CF 

PROVIDER: S-EPMC5034806 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature