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Virus-Surface-Mimicking Surface Clustering of AuNPs onto DNA-Entrapped Polymeric Nanoparticle for Enhanced Cellular Internalization and Nanocluster-Induced NIR Photothermal Therapy.

ABSTRACT: Virus-surface-mimicking decoration of deoxyribonucleic acid (DNA)-entrapped polymeric nanoparticle with AuNPs is demonstrated to lead to enhanced cellular uptake, improved gene transfection, and particularly efficient near-infrared photothermal therapy that cannot be achieved by both of them separately. This hybrid nanosystem represents a novel paradigm of multipurpose organic-inorganic nanoplatform, especially for cancer treatments.

SUBMITTER: Jia HZ

PROVIDER: S-EPMC5034825 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Virus-Surface-Mimicking Surface Clustering of AuNPs onto DNA-Entrapped Polymeric Nanoparticle for Enhanced Cellular Internalization and Nanocluster-Induced NIR Photothermal Therapy.

Jia Hui-Zhen HZ Chen Wei-Hai WH Wang Xuli X Lei Qi Q Yin Wei-Na WN Wang Yan Y Zhuo Ren-Xi RX Feng Jun J Zhang Xian-Zheng XZ

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20150714 12

<b>Virus-surface-mimicking decoration of deoxyribonucleic acid (DNA)-entrapped polymeric nanoparticle with AuNPs</b> is demonstrated to lead to enhanced cellular uptake, improved gene transfection, and particularly efficient near-infrared photothermal therapy that cannot be achieved by both of them separately. This hybrid nanosystem represents a novel paradigm of multipurpose organic-inorganic nanoplatform, especially for cancer treatments. ...[more]

PMID: 27708995

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