Neurocognition in individuals at high familial risk of mood disorders with or without subsequent onset of depression.

ABSTRACT:

Background

Neurocognitive performance deficits have been observed in mood disorder patients and their unaffected relatives and may therefore qualify as endophenotypes. However, the precise time course of neurocognitive deficits has not been studied so that it is unknown whether neurocognitive abnormalities reflect the early effects of familial vulnerability to mood disorders or if they emerge at illness onset.

Method

A neuropsychological test battery was administered at baseline and after a 2-year follow-up interval in 111 initially unaffected young adults at high familial risk of mood disorders and 93 healthy controls (HC). During the follow-up period, 20 high-risk subjects developed major depressive disorder (HR-MDD), with the remainder remaining well (HR-well). Linear mix

SUBMITTER: Papmeyer M 

PROVIDER: S-EPMC5034888 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature