Renal Impairment and Cardiovascular Disease in HIV-Positive Individuals: The D:A:D Study.

ABSTRACT:

Background

While the association between renal impairment and cardiovascular disease (CVD) is well established in the general population, the association remains poorly understood in human immunodeficiency virus (HIV)-positive individuals.

Methods

Individuals with ≥2 estimated glomerular filtration rate (eGFR) measurements after 1 February 2004 were followed until CVD, death, last visit plus 6 months, or 1 February 2015. CVD was defined as the occurrence of centrally validated myocardial infarction, stroke, invasive cardiovascular procedures, or sudden cardiac death.

Results

During a median follow-up duration of 8.0 years (interquartile range, 5.4-8.9 years) 1357 of 35 357 individuals developed CVD (incidence rate, 5.2 cases/1000 person-years [95% confidence interval

SUBMITTER: Ryom L 

PROVIDER: S-EPMC5034954 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature