Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection.

ABSTRACT:

Background

Fasciola hepatica is not only responsible for major economic losses in livestock farming, but is also a major food-borne zoonotic agent, with 180 million people being at risk of infection worldwide. This parasite is sophisticated in manipulating the hosts' immune system to benefit its own survival. A better understanding of the mechanisms underpinning this immunomodulation is crucial for the development of control strategies such as vaccines.

Methodology/principal findings

This in vivo study investigated the global gene expression changes of ovine peripheral blood mononuclear cells (PBMC) response to both acute & chronic infection of F. hepatica, and revealed 6490 and 2364 differential expressed genes (DEGS), respectively. Several transcriptional regulators were p

SUBMITTER: Fu Y 

PROVIDER: S-EPMC5035020 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature