Impact of Chronic Stress Protocols in Learning and Memory in Rodents: Systematic Review and Meta-Analysis.

ABSTRACT: The idea that maladaptive stress impairs cognitive function has been a cornerstone of decades in basic and clinical research. However, disparate findings have reinforced the need to aggregate results from multiple sources in order to confirm the validity of such statement. In this work, a systematic review and meta-analyses were performed to aggregate results from rodent studies investigating the impact of chronic stress on learning and memory. Results obtained from the included studies revealed a significant effect of stress on global cognitive performance. In addition, stressed rodents presented worse consolidation of learned memories, although no significantly differences between groups at the acquisition phase were found. Despite the methodological heterogeneity across studies, these e

SUBMITTER: Moreira PS 

PROVIDER: S-EPMC5035061 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature