Liver injury from nonsteroidal anti-inflammatory drugs in the United States.

ABSTRACT:

Background & aims

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used and have been associated with hepatotoxicity. Studies of liver injury from NSAIDs have been retrospective and prospective data are lacking. The aim was to report the features and outcomes of the subjects with severe drug-induced liver injury from NSAIDS.

Methods

The U.S. Drug Induced Liver Injury Network is a prospective registry of idiosyncratic drug hepatotoxicity. All patients are evaluated in a standard fashion and followed up for at least 6 months.

Results

Of 1221 Drug Induced Liver Injury Network cases that were adjudicated, 30 cases were attributed to eight different NSAIDs. The mean age was 52 years old, 24 (80%) were women, and 21 (70%) were Caucasian. The mean latency was 67 da

SUBMITTER: Schmeltzer PA 

PROVIDER: S-EPMC5035108 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature