MTR recovery in brain lesions in the BECOME study of glatiramer acetate vs interferon β-1b.

ABSTRACT:

Objective

To compare magnetization transfer changes in new brain MRI lesions identified during monthly imaging in patients with multiple sclerosis (MS) randomized to treatment with 250 μg subcutaneous interferon-β-1b (IFN-β-1b) every other day or daily 20 mg glatiramer acetate (GA) in a post hoc study using data from the Betaseron Versus Copaxone for Relapsing Remitting or CIS Forms of MS Using Triple Dose Gad 3 T MRI (BECOME) trial.

Methods

T1-weighted images acquired with and without fat saturation pulses in the BECOME study were evaluated and found to exhibit magnetization transfer ratio (MTR) effects, and were used to compute MTR images (FSMTR). Forty-three participants who had the required imaging and new lesions, from the 75 originally randomized into the BECOME study,

SUBMITTER: Brown RA 

PROVIDER: S-EPMC5035157 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature