Quantifying six-minute walk induced gait deterioration with inertial sensors in multiple sclerosis subjects.

ABSTRACT:

Background

The six-minute walk (6MW) is a common walking outcome in multiple sclerosis (MS) thought to measure fatigability in addition to overall walking disability. However, direct evidence of 6MW induced gait deterioration is limited by the difficulty of measuring qualitative changes in walking.

Objectives

This study aims to (1) define and validate a measure of fatigue-related gait deterioration based on data from body-worn sensors; and (2) use this measure to detect gait deterioration induced by the 6MW.

Methods

Gait deterioration was assessed using the Warp Score, a measure of similarity between gait cycles based on dynamic time warping (DTW). Cycles from later minutes were compared to baseline cycles in 89 subjects with MS and 29 controls. Correlation, corrected

SUBMITTER: Engelhard MM 

PROVIDER: S-EPMC5035201 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature