Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis.

ABSTRACT:

Background

Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration could enable a more integrated approach than at present by predicting heart failure and enhancing coronary heart disease and stroke risk assessment.

Methods

In this individual-participant-data meta-analysis, we generated and harmonised individual-participant data from relevant prospective studies via both de-novo NT-proBNP concentration measurement of stored samples and collection of data from studies identified through a systematic search of the literature (PubMed, Scientific Citation Index Expanded, and Embase) for articles published up

SUBMITTER: Natriuretic Peptides Studies Collaboration 

PROVIDER: S-EPMC5035346 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature