Genetic variations in the Hippo signaling pathway and breast cancer risk in African American women in the AMBER Consortium.

ABSTRACT: The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. Dysfunction of the Hippo pathway components has been linked with breast cancer stem cell regulation, as well as breast tumor progression and metastasis. TAZ, a key component of the Hippo pathway, is highly expressed in triple negative breast cancer; however, the associations of genetic variations in this important pathway with breast cancer risk remain largely unexplored. Here, we analyzed 8309 germline variants in 15 genes from the Hippo pathway with a total of 3663 cases and 4687 controls from the African American Breast Cancer Epidemiology and Risk Consortium. Odds ratios (ORs) were estimated using logistic regression for overall breast cancer,

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5035397 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature