COMT, BDNF, and DTNBP1 polymorphisms and cognitive functions in patients with brain tumors.

ABSTRACT:

Background

Cognitive dysfunction is common among patients with brain tumors and can be associated with the disease and treatment with radiotherapy and chemotherapy. However, little is known about genetic risk factors that may moderate the vulnerability for developing cognitive dysfunction. In this study, we examined the association of single nucleotide polymorphisms (SNPs) in the catechol-O-methyl transferase (COMT), brain-derived neurotrophic factor (BDNF), and dystrobrevin-binding protein 1 (DTNBP1) genes with cognitive functions and neuroimaging outcomes in patients with brain tumors.

Methods

One hundred and fifty patients with brain tumors completed neuropsychological tests of attention, executive functions, and memory and were genotyped for polymorphisms in the COMT, BD

SUBMITTER: Correa DD 

PROVIDER: S-EPMC5035520 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature