HIV Infection, Tenofovir, and Urine α1-Microglobulin: A Cross-sectional Analysis in the Multicenter AIDS Cohort Study.

ABSTRACT:

Background

Tenofovir disoproxil fumarate (TDF) can cause proximal tubular damage and chronic kidney disease in human immunodeficiency virus (HIV)-infected individuals. Urine α1-microglobulin (A1M), a low-molecular-weight protein indicative of proximal tubular dysfunction, may enable earlier detection of TDF-associated tubular toxicity.

Study design

Cross-sectional.

Setting & participants

883 HIV-infected and 350 -uninfected men enrolled in the Multicenter AIDS Cohort Study.

Predictors

HIV infection and TDF exposure.

Outcome

Urine A1M level.

Results

Urine A1M was detectable in 737 (83%) HIV-infected and 202 (58%) -uninfected men (P<0.001). Among HIV-infected participants, 573 (65%) were current TDF users and 112 (13%) were past TDF users. After mul

SUBMITTER: Jotwani V 

PROVIDER: S-EPMC5035569 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature